首页关于道一研发平台优势产品在研管线商业模式合作洽谈

三层结构

Three-layer structure

道一提供核酸药物的一体化递送设计服务(RNA-ADD)。客户带来 RNA 货物与目标组织,我们交付脂质材料、LNP 处方与完整的体内外验证证据 —— 并以现货工具、服务、管线三层结构把「递送能力」变成可持续的生意。

Harmony Tao provides integrated delivery design services for nucleic acid drugs (RNA-ADD). Customers bring the RNA cargo and the target tissue; we deliver lipid materials, LNP formulations and full in vitro / in vivo evidence — turning delivery capability into a sustainable business through three layers: reagent product, services and pipeline.

Layer 1

工具产品层:Lipoeasy® 即用型转染试剂

Tool layer — Lipoeasy® ready-to-use transfection reagent

标准化现货产品,替代 Lipo-fectamine 3000 与进口体内转染试剂的高门槛方案。低单价、可复购、易触达,是最前端的客户入口与现金流。

A standardised off-the-shelf product replacing the high-threshold Lipo-fectamine 3000 and imported in vivo reagents. Low unit price, repeat purchase, easy reach — the front door to customers and to cash flow.

现货 · 复购 · 获客入口
Layer 2

服务层:RNA-ADD 一体化递送设计

Service layer — RNA-ADD integrated delivery design

以平台四项资产为客户做定制递送设计:脂质材料选型或定制合成、LNP 处方筛选与理化表征、体内外转染验证、动物药效评价。按项目收费,收入体量大、客户黏性高。

Custom delivery design using the four platform assets: lipid selection or custom synthesis, LNP formulation screening and characterisation, in vitro / in vivo transfection validation, animal efficacy evaluation. Project-based fees, larger tickets, stickier customers.

定制 · 项目制 · 数据沉淀
Layer 3

管线层:自研与合作管线

Pipeline layer — proprietary and partnered programmes

HT001(肝靶向基因编辑)与 HT002(脾靶向 in vivo CAR-T)由自有平台孵化,走联合开发或许可授权。这是长期价值出口,也是平台能力的最强证明。

HT001 (liver-targeted gene editing) and HT002 (spleen-targeted in vivo CAR-T) are incubated on the platform and advanced through co-development or licensing. This is the long-term value outlet and the strongest proof of platform capability.

授权 · 联合开发 · 高价值

闭环逻辑

Why the three layers reinforce each other

工具层带来客户与场景服务层沉淀处方与体内外数据数据训练 AI 预测模型模型提升服务与管线成功率管线成果反哺品牌与获客

RNA-ADD 服务内容

What RNA-ADD covers

脂质材料与配体选型 / 定制合成

Lipid and ligand selection / custom synthesis

从 Lipid 分子库与 Ligand 结构库中匹配靶组织,或按需定制合成。

Match the target tissue from the lipid and ligand libraries, or synthesise to order.

LNP 处方筛选与理化表征

LNP formulation screening and characterisation

粒径、分散度、表面电位、包封率等参数表征,形成可复现处方。

Size, dispersity, surface charge and encapsulation efficiency — a reproducible formulation.

体内外转染验证

In vitro and in vivo transfection validation

以 Lipoeasy® 工具快速完成细胞层面与动物层面递送验证。

Rapid delivery validation at cell and animal level using the Lipoeasy® tool.

动物药效评价

Animal efficacy evaluation

在目标适应症模型上评价递送方案的实际药效表现。

Evaluating real efficacy of the delivery scheme in the target indication model.

AI 预测与配方优化

AI prediction and formulation optimisation

用体内外预测模型缩小候选范围,减少试错轮次。

In vitro / in vivo models narrow the candidate space and cut trial-and-error rounds.

合作方式

Ways to work with us

递送设计服务

Delivery design service

适用于已有 RNA 货物、需要解决靶向或安全性问题的团队。

For teams that already have the RNA cargo and need targeting or safety solved.

试剂供应与定制

Reagent supply & customisation

采购 Lipoeasy® 现货试剂,或按转染需求定制规格与批量。

Buy off-the-shelf Lipoeasy®, or customise spec and bulk for your transfection needs.

管线联合开发 / 授权

Co-development / licensing

围绕 HT001、HT002 及新靶组织方向开展联合开发或授权合作。

Co-development or licensing around HT001, HT002 and new target-tissue directions.

聊聊您的递送难题

Tell us your delivery problem

把货物类型、目标组织和当前阶段告诉我们,我们会给出具体的递送路线建议。

Give us the cargo, the target tissue and your stage — we will propose a concrete delivery route.